Laboratory Operations
CLIA Competency Assessment for High-Complexity Labs
I want to start with a scene that plays out in high-complexity labs more often than anyone wants to admit.
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Precision Medicine
Broad CGP vs Targeted Hotspot Panels in Oncology
The central mistake in oncology assay selection is treating genomic breadth as a virtue in itself. It is not. A broad…
Clinical Microbiology
C. Difficile Diagnostics: A Case of PCR Overdiagnosis
A positive nucleic acid amplification test does not, by itself, establish active Clostridioides difficile infection. That…
Digital Pathology & AI
Stain Normalization: How Algorithms Standardize Slides
A whole-slide imaging program can have excellent scanners, validated classifiers, and experienced pathologists—and still produce…
Molecular Diagnostics
Multiplex PCR Panels: Clinical Impact and Real Utility
A randomized controlled trial published in JAMA Network Open in 2024 found that emergency department patients with suspected…
Laboratory Operations
Specimen Chain of Custody: Fixing Preanalytical Lab Risks
Between 60% and 70% of all laboratory errors originate in the preanalytical phase — the operational interval that begins with…
Precision Medicine
Liquid Biopsy or Tissue Testing for First-Line Therapy?
Turnaround time is a cost center. In advanced non-small-cell lung cancer, published clinical data demonstrate that plasma ctDNA…
Clinical Microbiology
MALDI-TOF Mass Spectrometry Errors: A Diagnostic Case
A MALDI-TOF result can look definitive even when the organism in front of you is telling a different story.
Digital Pathology & AI
Deep Learning Slide Pipelines: How AI Processes Tissue Patches
There's a persistent fantasy in computational pathology that AI looks at a slide the way a pathologist does — holistically, all…
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